Unmatched Evidence

Cook Medical

Two decades of evidence, including over 30 peer-reviewed studies and meta-analyses, confirm that minocycline and rifampin (M+R) catheters are an effective tool to provide broad-spectrum protection against gram-positive, gram-negative, and some fungal infections in both short- and long-term use.

Process Alone and Process Plus Antimicrobial Catheter Technology

CRBSI rate

CRBSI rate
A comparative study

Process with uncoated catheter Process with Ch-SS+ (AGB+) Process with M+R
3.3 1
2.7 2
1.4 2

Infections per 1,000 Catheter Days

Infections per 1,000 Catheter Days

Process MSB technique alone M+R Cook Spectrum®
Ch-SS+ ARROWg+ard® Blue Plus®

Efficacy of Antimicrobial Catheter Technologies Against Various Infections 3

Gram Positive Gram Negative Fungal
1.03
.45
.51
.45
.51
.25

Infections per 1,000 Catheter Days

Ch-SS+ ARROWg+ard® Blue Plus® M+R Cook Spectrum®
References – Unmatched Evidence
  1. Schuerer DJ, Zack JE, Thomas J, et al. Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial. Surg Infect (Larchmt). 2007;8(4):445-454.
  2. Bonne S, Mazuski J, Sona C, et al. Effectiveness of minocycline and rifampin vs chlorhexidine and silver sulfadiazine-impregnated central venous catheters in preventing central line-associated bloodstream infection in a high-volume academic intensive care unit: a before and after trial. J Am Coll Surg. 2015;221(3):739-747.
  3. Schuerer DJ, Mazuski JE, Buchman TG, et al. Catheter-related bloodstream infection rates in minocycline/rifampin vs. chlorhexidine/silver sulfadiazine-impregnated central venous catheters results of a 46 month study. Crit Care Med. 2008Íž36(12)(suppl):A199A208. Abstract 454.