Two prospective studies have examined the susceptibility of clinical isolates to the development of antibiotic resistance from M+R CVC use.3,4 None of the studies showed any association between M+R and antibiotic resistance, nor did a 7-year study of over 500,000 catheter days.1,2
References - No Evidence of Increased Resistance
Darouiche RO, Raad II, Heard SO, et al. A comparison of two antimicrobial-impregnated central venous catheters. N Engl J Med. 1999;340(1):1–8.
Raad I, Darouiche R, Dupuis J, et al. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections: a randomized, double-blind trial. Ann Intern Med. 1997;127(4):267–274.